Generic Vardenafil, which is one of the three most often prescribed PDE5 inhibitors for dealing with male impotence, is better known under its brand name Levitra. Despite having a lot in common with sildenafil and tadalafil, generic Vardenafil has some benefits attracting the attention of new users.
Mechanism of action
The effect of generic Vardenafil can only be triggered by sexual stimulation or sexual arousal. The pill can’t provide an erection without these conditions being fulfilled.
The work of Vardenafil lies with the inhibition of phosphodiesterase type 5 production. This chemical prevents muscle relaxation. Cutting back on its production, generic Vardenafil helps the growth of cyclic guanosine monophosphate levels. The latter induces the relaxation of the cavernous bodies muscles in the penis as well as widening of the blood vessels leading to the penile area.
Both effects enhance the inflow of the blood to the genitals thus enabling men achieve and mainaint the erection. According to the study published in the Canadian Urological Association Journal, 81% of men could successfully penetrate partner’s vagina after taking generic Vardenafil for the first time. 70% were able to maintain erection throughout the intercourse.
Dosages and recommendations on intake
The dosage one has to take should be determined by the attending doctor as it may vary depending on the overall health condition of the patient, the severity of ED symptoms, and individual tolerance to the drug.
Generic Vardenafil is manufactured in 5mg, 10mg, and 20mg dosages. For the bulk of men with ED, the recommended starting dose of the drug is 10mg. A lower dose is commonly prescribed to men having a high probability of evolving side effects and those who are 65 and older. A lack of efficacy of the initial dose may mean that the dosing regimen has to be changed to 20mg of generic Vardenafil a day.
The drug should be administered 15-60 minutes prior to the anticipated sexual intercourse. Generic Vardenafil is not intended for daily use. If needed, make sure there is a 24-hour break between the pills. In most men, 25 minutes is the average time of the drug effect onset. Use Vardenafil on an empty stomach to speed up the start of its action. In general, the duration of the effect is 4-5 hours.
Usage with caution
Caution is needed when generic Vardenafil is prescribed to patients with:
- Severe liver dysfunction;
- Renal impairment;
- Vision problems (NAION, optic nerve abnormalities);
- Deformations or scarring of the penis;
- Priapism in medical history;
- Hypotension or uncontrolled hypertension;
- Blood disease;
- Stomach ulcers;
- QT interval prolongation;
- Heart disease (coronary artery disease, unstable angina).
There are also certain restrictions concerning the amounts of alcohol which may safely be consumed when on Vardenafil. The commonly accepted norm is three units of alcohol a day. Larger doses can affect the efficiency of the drug and elevate the risks for unwanted effects.
Grapefruit juice may become the cause of generic Vardenafil overdose as it changes the speed of the drug absorption from the gastric tract. In this connection it is best avoided it for at least 24 hours before and after taking the pill.
Contraindications to generic Vardenafil
Generic Vardenafil can never be prescribed to women or children younger than 18. People who are hypersensitive to Vardenafil or some other constituents of the drug must never use it. Generic Vardenafil and sexual activity associated with it are contraindicated in men with severe heart illnesses who risk having a stroke or a heart attack because of the excessive physical strain.
Possible side effects
The study carried out by Japanese scientists revealed that the incidence of side effects of Vardenafil strongly depends on the dose administered. The rates were 35.3%, 45.3%, and 54.5% for the doses of 5mg, 10mg, and 20mg respectively.
The common side effects of generic Vardenafil are:
- Back pain;
They are all temporary and disappear within several hours. Still, you can consult your attending doctor to make sure these reactions pose no risk for health. As to the more serious Vardenafil adverse effects, they are:
- Low blood pressure;
- Nasal bleeding;
- Vision changes;
Any of these reactions should be discussed with a specialist. Turn to the nearest hospital in case your symptoms persist or get worse.
Interaction with other drugs
Vardenafil may dangerously interact with nitrate medications for lowering the blood pressure. Acting in synergy, these drugs can provoke a drop in blood pressure, which is difficult to stabilize. Other drugs, which may be harmful in combination with generic Vardenafil are:
- HIV protease inhibitors;
- Some antibiotics (e.g. erythromycin);
- Some azole antifungals;
- PDE-5 inhibitors.
Generic Vardenafil overdose
To avoid Vardenafil overdosing, it is important not to take more than one 20mg pill per 24 hours. But if it happened so that you did take more, contact your doctor immediately as you are likely to experience faintness, breathlessness, nausea, chest discomfort and some more symptoms, which are mainly connected with a serious drop in the blood pressure. Seek for help once you notice the initial signs of overdose.
Keep the drug away from children and animals. Store it at room temperature away from moisture and light.
Generic Vardenafil has no potential for being a toxic substance.
Generic Vardenafil doesn’t cause addiction and is safe in this regard even in long-term use.