Generic Tadalafil is a drug of choice for 71% of men suffering from the erection troubles. This medication is manufactured by Eli Lilly company under the brand name Cialis. The drug has a whole range of specifics, which make it different from other PDE5 inhibitors. Are you interested? Read on to know more.
Generic Tadalafil mechanism of action
Getting into the human organism, Tadalafil works by inhibiting the production of phosphodiesterase type 5. Thanks to this the growth in the levels of cyclic guanosine monophosphate (cGMP) becomes possible. This substance takes part in the process of relaxing the smooth muscular tissue in the penis and the blood vessels thus letting them expand.
A combination of these effects helps to enhance the inflow of blood to the pelvic organs and genitals in particular. So, when a penis is filled with sufficient amount of blood, a man can get and sustain an erection which is hard enough for sexual activity.
Those who don’t want their sexual partner to know about their taking generic Tadalafil, can skip worrying because the action of the drug is “turned on” only when a man feels sexual desire or gets sexually stimulated.
What is the dosing regimen and how to take the drug?
A feature that makes generic Tadalafil different from other ED medications is that it can be applied either when it is needed or on a daily basis. The dose is prescribed relying on the frequency of intake.
For everyday administering of generic Tadalafil, 2.5mg or 5mg doses are applied, whereas 10mg and 20mg doses should be taken only when a man is planning to have sexual contact. In the first case, the time gap between two pills taken should be at least 24 hours.
The drug can start working anywhere between 16 and 40 minutes after the intake. It depends on the person’s response to the drug and the dose used. The key benefit of generic Tadalafil is that its duration of action can reach up to 36 hours so that a man can take the pill once in three days.
Food doesn’t influence generic Tadalafil absorption from the gastric tract. Hence, it may be administered regardless of meals.
Precautions to the drug usage
Generic Tadalafil should be prescribed with caution to patients with the following health conditions:
- Uncontrolled hypertension or hypotension;
- Heart disease (heart failure, angina);
- Blood cells disease (leukemia, sickle cell anemia);
- Stomach ulcer;
- Penis deformation (Peyronie’s disease);
- Serious kidney or liver dysfunction;
- A stroke, a heart attack or heart surgery in the last 6 months.
Due to the hypotensive effect of the drug, it is not recommended to use it with excessive amounts of alcohol as the latter can exacerbate the blood pressure lowering effect leading to vertigo. For the same reason, the use of cannabis should be stopped once you start the therapy with generic Tadalafil.
Grapefruit juice can affect the concentration of Tadalafil in the blood raising it. Consequently, it elevates the probability of overdose.
Generic Tadalafil contraindications
Any patient starting the treatment with generic Tadalafil should discuss its safety with his healthcare provider. What categories of patients should not take this drug? They are:
- Males who are not allowed to experience serious physical strain due to severe heart disease;
- Individuals younger than 18;
- Men who are allergic to Tadalafil or any other inactive component of the remedy.
Generic Tadalafil can be used in women for pulmonary arterial hypertension therapy. The drug may be applied during pregnancy only when clearly needed. It is not known whether Tadalafil gets into breast milk.
Adverse reactions to the drug
Anyone who is going to take Tadalafil for the first time wonders about the probable side effects. An estimate of about 51% of men experiences at least one of Tadalafil side effects. Among them there are:
- Stuffy or runny nose;
- Back pain;
- Muscular pain;
- Facial flushes.
None of these symptoms are serious. They commonly go away together with the effect of the drug. Yet if the unwanted reactions persist or gets worse, contact your healthcare provider.
The results of the studies claim that about 8.6% of patients taking generic Tadalafil can face severe side effects. They may manifest through:
- Low blood pressure;
- Vision changes (blurred vision, color blindness);
- Partial or complete hearing loss;
- Pain in the chest, which spreads to the arms, jaw, neck, and back, changes in the heart rhythm signaling about heart attack;
- Priapism (painful erection continuing more than 4 hours).
Immediate medical attention is a must in any of the enumerated adverse effects.
Those patients who take certain other drugs except for generic Tadalafil should discuss the safety of their interaction with their attending doctor. Generic Tadalafil shouldn’t be taken with:
- PDE5 inhibitors;
- HIV protease inhibitors;
- Antihypertensive medicines;
- Some antibiotics.
Intake of other preparations should be coordinated with a healthcare provider too.
Generic Tadalafil overdose
You should never take more generic Tadalafil than you were prescribed. An excess of Tadalafil in the blood increases the likelihood of getting side effects including the severe ones. In case of taking an overdose, contact your doctor. If you feel difficulties with breathing, seek emergency help.
The drug should be stored at room temperature away from light and moisture. Make sure children and pets do not have access to the drug.
Tadalafil is not known for any toxic effect on the human organism.
Numerous studies haven’t revealed any potential for generic Tadalafil being addictive.