Generic Priligy is the only drug approved for premature ejaculation therapy in more than 50 countries of the world. The active component of the pill is dapoxetine. The substance is approved for the use in PE patients by the FDA, its efficacy and safety have been proven by millions of men who have difficulties with ejaculation control.
According to the Indian Journal of Urology, 4% – 39% of men face the problem of premature ejaculation; this drug gives hope for normal sexual life to a third of the world’s male population. Go on reading to learn about everything you should know about generic Priligy.
Mechanism of Action
To help you understand the way generic Priligy assists in the delay of ejaculation, it is important to know how the emission of semen during the intercourse happens. The signals sent from the genital stimuli are processed in the spinal cord. Then the command is transitioned to the brain. The latter, in its turn, sends the nerve impulse to the male sex organs and the ejaculation takes place.
There is still no common thought about the exact mechanism of generic Priligy action. However, it is confirmed that dapoxetine inhibits serotonin neuronal reuptake and thus increases the influence of the latter on certain receptors in the brain. As a result, the speed of the signal transition from the brain to the genitals gets reduced and the ejaculation is delayed.
Dosages and recommendations on usage
Generic Priligy is available in two dosages: 30 mg and 60 mg. The commonly recommended starting dose of the drug is 30mg. An increase in the dose is only recommended if the initial one hasn’t worked well enough and there were little to no adverse reactions.
This preparation should be used only when you plan sexual activity. Take generic Priligy 1-3 hours before the anticipated intercourse. The tablets may be used regardless of meals. In case there is a need to apply the drug two or more days in a row, make sure there’s a 24-hour gap between the pills’ intake.
The duration of treatment should be determined by a specialist only. A check-up with a doctor is needed after the first four weeks of treatment. If the results are satisfying, the therapy may be continued for six more months. The safety of generic Priligy in the period exceeding 24 weeks hasn’t been properly studied yet. A longer therapy course is therefore not recommended unless your doctor approves it.
Using with caution
The potential benefits and risks for generic Priligy use should be evaluated prior to prescribing this medication to men with:
- Liver disease;
- Renal impairment;
- Cardiovascular problems (coronary artery disease, valvular heart disease);
- High intraocular pressure;
- A potential for closed-angle glaucoma development;
- Bleeding problems;
Men also have to avoid driving and operating machinery as generic Priligy may cause dizziness and syncope. The remedy should be applied with caution in patients with mental health issues (especially suicidal thoughts) in medical history.
Contraindications to generic Priligy
There are certain categories of patients whose risks obviously prevail the benefits of taking generic Priligy. That’s why men with the following health conditions should never use this drug:
- Allergy to dapoxetine or any inactive component of the drug;
- Age younger than 18 an older than 64;
- Severe heart disease (heart block, sick sinus syndrome, heart failure);
- Heart attack in medical history;
- Serious liver and kidney issues;
- Hereditary galactose intolerance;
- A history of serious depression, mania, and bipolar affective disorder.
The preparation should never be used in males with a permanent pacemaker. Drinking alcohol significantly elevates the risks of adverse events connected with dizziness and syncope. That’s why it is better to avoid their concomitant intake.
Possible side effects
Any man starting generic Priligy intake has to know about the adverse reactions he may face with. According to the study, the most frequent unwanted effects induced by dapoxetine are:
- Sleeping problems;
- Extreme tiredness.
The rarer side effects of the drug are the following:
- Low libido;
- Difficulty concentrating;
- Blurred vision;
- Nasal congestion;
- Difficulty getting an erection;
- Raise in the blood pressure.
Any of the mentioned above reactions should be discussed with your attending doctor. In case some of these symptoms get worse or stay for too long, seek medical attention.
Interaction with other medications
The question of drug interactions safety is very important for anyone administering several different preparations. Speaking about generic Priligy interactions, it is prohibited to use it together with:
- Monoamine oxidase inhibitors;
- Tricyclic antidepressants;
- Serotonin-norepinephrine reuptake inhibitors;
- Ketoconazole, itraconazole, ritonavir;
- John’s Wort;
- Other preparations possessing serotonergic effect.
Any of these medications may be taken not earlier than in 7 days after generic Priligy discontinuation. In the opposite situation, the usage of generic Priligy will be safe only after 14 days after any of the mentioned remedies is discontinued.
You should strictly follow the doctor’s recommendations to avoid drug overdose. Yet, if this has happened, you are likely to experience dizziness, tremor, nausea, vomiting, increased heart rate, sleepiness. Turn to the nearest hospital once you notice any signs of Priligy overdose.
Store the drug at room temperature away from moisture and light. Keep it out of reach of children and pets.
The study on the drug toxicity was performed in animals only. Based on the results, the medication has a moderate order of acute toxicity. The major systems affected were the CNS, liver, and kidneys.
Abrupt discontinuation of SSRI, which generic Priligy is, may lead to dizziness, agitation, headache, insomnia, lethargy, and some other symptoms. That’s why one has to withdraw from dapoxetine treatment by gradually reducing the dose. However, on-demand use of generic Priligy significantly lowers the probability of withdrawal syndrome development.