Avanafil is a real finding for those who suffer vision changes, myalgia, and QT prolongation when taking other PDE5 inhibitors. Due to improved formula, Avanafil minimizes the risks for the mentioned adverse reactions and works twice as fast as sildenafil, tadalafil or vardenafil.
Another benefit of the drug is that it works equally well for men with or without diabetes. Besides, if compared to other PDE5 inhibitors, Avanafil has less impact on the blood pressure numbers, which is good news to those suffering from ED and hypotension.
Mechanism of action
Getting into the blood flow, Avanafil inhibits the secretion of phosphodiesterase type 5, which prevents cGMP levels from growth. When a man gets sexually stimulated, growing amounts of nitric oxide are produced by the nerve endings located in the penis. Thanks to this, the levels of cGMP raise, which makes the relaxation of the penile muscular tissue and the blood vessels extension possible.
The result of this mechanism is an enhanced inflow of blood to the penile area, and, consequently, strong and durable erection.
Dosages and recommendations on Avanafil intake
There are three dosages of Avanafil available: 50mg, 100mg, and 200mg. As a rule, the recommended starting dose of Avanafil is 100mg taken about 15-25 minutes prior to sexual intercourse. In case the dose is not effective a patient may be advised to take 200mg Avanafil. But if the effect was too strong or some unwanted reactions have appeared, it is better to lower the dose to 50mg.
Avanafil should be taken only before a planned sexual activity. The drug is not suitable for daily intake. Nevertheless, if there’s such a need, a man may take another dose 24 hours later.
Fatty food can influence the absorption of Avanafil, so it is best to administer the drug without meals, otherwise the effect may be delayed for up to 1.25 hours. Take Avanafil with a full glass of water. The duration of the drug’s effect is about 6 hours.
When should Avanafil be used with caution?
Trying to deal with ED, it is important not to forget about other health issues you may suffer from, as they may have a direct impact on the ED treatment tactics. That is why you have to inform your healthcare provider about all the health conditions you currently have and those you have recently coped with. Tell your doctor if you have:
- Serious heart issues (coronary artery disease, aortic stenosis);
- Serious kidney or liver dysfunction;
- Cases of priapism in medical history;
- Blood cell disorders (sickle cell anemia, leukemia);
- Peptic ulcer;
- Bleeding disorders;
- Uncontrolled high blood pressure.
Patients taking Avanafil should limit their consumption of alcohol to a maximum of three drinks a day to cut the risks for side effects. Unlike alcohol, whose use can be simply limited, one should completely avoid grapefruit juice when on Avanafil. This product has the potential for affecting the speed of Avanafil metabolism. In this connection, the concentrations of the drug in the blood may get significantly higher. It may lead to overdose and elevate the probability of adverse reactions.
Be careful when driving or operating machinery after Avanafil intake because there is a probability of faintness and somnolence.
Contraindications to Avanafil
Contraindications list can play a crucial role in the choice of drug. Speaking about Avanafil, it shouldn’t be used in men with:
- Hypersensitivity to Avanafil;
- Severe heart issues, which make sexual activity dangerous;
- Heart attack, stroke or heart surgery within the last 6 months;
- Serious hypotension.
Avanafil should not be used by women and children under 18.
Possible side effects
To know what to expect from the pills you’ve been prescribed, it is important to learn about the adverse reactions you may experience while using Avanafil. The most common of them are:
- Nasal congestion;
- Back pain;
- Upper respiratory tract infections;
- Elevated blood pressure.
The bulk of the listed reactions go away on their own after the effect of the drug wears off. They usually don’t need medical help. However, if you feel worried about the seriousness or the duration of the adverse effects, you’d better contact your healthcare provider for consultation.
As for the more serious symptoms one may have, they are:
- Pain in muscles or extremities;
- Extreme tiredness;
- Palpitations, angina;
- Rise or fall in the blood glucose levels;
- Urinary tract infection.
Inform your attending doctor once you notice any serious undesirable reactions. Turn for emergency help in case your condition persists or gets worse.
Avanafil drug interactions
You should provide the information about all the medicines you use to your attending doctor prior to starting on Avanafil. It is important because some preparations may dangerously interact with it. When on Avanafil, avoid taking:
- Nitrate drugs;
- Blood pressure lowering drugs;
- HIV protease inhibitors;
- Macrolide antibiotics;
- Hepatitis C virus protease inhibitors;
- Other PDE-5 inhibitors.
“Poppers”, which are recreational drugs, can also be dangerous in combination with Avanafil as they increase its vasodilatory effect and may stimulate a serious fall in the blood pressure. Administering of some herbal products for curing erectile dysfunction may also affect the action of Avanafil.
In the case of an overdose on Avanafil, you should turn to the nearest hospital. Standard supportive measures should be applied to such patients. The reaction to excessive doses of the drug is similar to the common side effects. However, their occurrence and severity get much higher.
Avanafil doesn’t require any special storage conditions. Just keep it at room temperature away from light and moisture. Make sure kids and animals have no access to the drug.
Avanafil clinical studies didn’t reveal any drug toxicity. Yet, the issue still needs to be studied.
Avanafil has no potential for addiction.